Personally, I disabled the script that updates locatedb -- I got tired of it running at the worst possible times.

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For those looking to disable updating of the locate database, commenting the appropriate lines in /private/etc/periodic/weekly/500.weekly should work.
To check what configuration file is used, read the source of the /usr/sbin/periodic script.

Other solution: set the weekly maintenance script to run at a better time. Use lingon to edit launchd configuration files.

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This 500.weekly file located in /private/etc/periodic/weekly/ no longer seems to exist in 10.8 ... there are two files there, but neither contain anything about the locate database to comment out. Perhaps something changed with Mountain Lion? I would like to skip the updating of the locate database altogether. Fairly useless to me.

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