I very rarely get spam. Here is how:

1) I submit all my spam to SpamCop at:
http://www.spamcop.net/

It is a free service, but I have been a financial supporter since it started in 1998. The paid version is extremely inexpensive, particularly when considering the results. I receive so little spam that I am convinced that my consistent contributions to SpamCop have put me on a circulated 'Do Not Spam' list among the spamrats. The more spam submitted to SpamCop, IMHO, the less spam all of us would receive. This is thanks to them providing a carefully verified FREE blacklist of known spammers to the world.

There have been criticisms in the past of false positives due to SpamCop, but I seriously doubt this is possible at this point of time after their implementation of stringent verification. Meanwhile, I have repeatedly heard from the spamrat underground their contempt for SpamCop due to its effectiveness.

2) I use MobileMe's email. This is the specific email address where I rarely receive email. Whereas, I receive a lot of spam via my GMail address, one that I very rarely use and never publish anywhere. I have to applaud Apple's spam filtering.

In my experience, Gmail has an excellent spam filter. It catches about 99.9% of my spam. Mail catches about half of what gets through, and the rest gets through and I have to mark it as spam manually. And false positives virtually never happen.