The Quark 7 (and possibly 6, I don't remember) installer was horrible in that it reset the permissions on every file in the folder enclosing the new Quark folder, which, in most cases, would be your Applications folder. I actually had a Quark representative on site when I discovered this, and his eyes got real big when I showed it to him (the permissions repair after that took 30-40 minutes of constant scrolling in the Repair Permissions window.) The workaround was to make a new, empty folder and then tell Quark to install inside of THAT folder, then after installation, move the newly-created Quark folder into the main Applications.

I haven't seen any other installer so poorly behaved since then, but it sure is possible. Epson might have some issues--I see tons of Epson file permissions get repaired on many client machines I work on.