The Accessibility pane of System Preferences holds a number of interesting adjustments you can set to make your Mac easier to use. One of them is the ability to change the size of the cursor; the pointer you see on your screen.
Go to System Preferences > Accessibility, then click on Display. Drag the Cursor Size slider from Normal (smallest) toward Large. Find the size you want to use, and close the preference pane.
I have a 27" Thunderbolt Display, and I find the normal-sized cursor a bit small, so I've set mine to be a bit larger. You may find this to be a useful tweak as well.
Note that some applications may not use the changed setting. Feel free to post in the comments any apps that don't inherit this setting.
Mac OS X Hints
http://hints.macworld.com/article.php?story=20130415031012570