Chromium (and Chrome) has lots of useful features that can only be enabled via command line switches when launching, such as extensions, user script support, and bookmark sync.
Rather than launch via the command line every time, I use the following script to patch the --enable-extensions command line arguments into the application bundle itself:
#!/bin/sh
# Patches the Chromium application installation with command line arguments to enable extensions.
set -o errexit
app=${1:-/Applications/Chromium.app}
cat >$app/Contents/MacOS/Chromium.wrapper <<EOF
#!/bin/sh
exec $app/Contents/MacOS/Chromium --enable-extensions "\$@"
EOF
chmod 755 $app/Contents/MacOS/Chromium.wrapper
defaults write $app/Contents/Info CFBundleExecutable Chromium.wrapperMac OS X Hints
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