With Glims for Safari it is possible, among other things, to add custom search engines to Safari. You can also search within your Gmail inbox this way. With a keyboard shortcut assigned, it proves a quick way to search and acces your inbox.
Add this query URL for the custom search engine:
http://mail.google.com/mail/?hl=en&tab=wm#search/,#query#
[robg adds: I haven't tested this one. If you're using Snow Leopard, you'll either have to run Safari in 32bit mode, or wait for an updated version of Glims (which is apparently in the works, based on comments the Glims developers have made).]
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Mac OS X Hints
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