This has been an issue with my wireless Apple Mighty Mouse and Apple Wireless Keyboard (both white and aluminum keyboards).

I often turn off those devices during the day when I'm at work.

I've found that if I turn on my mouse before my keyboard, the mouse cursor has a jittery action to it.

When I turn the mouse off, then on again, it's fine.

So my solution in my situation has been to simply turn the keyboard on *before* the mouse, and all is well.

I've had problems time to time where mouse clicks failed. I could move the mouse around but no clicks registered. When I was using a BlueTooth keyboard and a Bluetooth mouse I never found a good solution, sometimes just fooling around with Force Quit would restore things.

Now I have an aluminum USB keyboard and unplugging the keyboard does cure a click failure with the mouse. I switched back to a wired mouse as well since I figure there's not a lot of need for wireless when I'm sitting in front of a 20" display with a wired keyboard.

It's a rare problem, it seldom happens much with this current setup, it was a bigger issue when everything was BlueTooth.

Another thing I've found works is to turn off the Airport wireless. I've seen this clear up the issue many times, and subsequently turning it back on after a moment continues to work.

Bluetooth and 802.11g/b use parts of the same wireless spectrum. Bluetooth tolerates this well, but it seems that in some cases the retransmissions and collisions get out of hand in the OS X implementation or in the wireless keyboard/mighty mouse firmware. I have not seen this issue for a while now, so it might have been fixed in.