Copy the following AppleScript into Script Editor, and save as an application:
To use the script, drop a PDF (or multiple PDFs) onto this application, and an internet location file/s will be created in the same folder. Drag these internet location files into Safari's Bookmarks window. Now sync your iPhone/Touch (make sure you have it set to sync Safari bookmarks) and open one of these bookmarks.Mac OS X Hints
http://hints.macworld.com/article.php?story=20080725071447247