Many of us have found a profiles.bin file in our home folders. Many think it is created by MS Office for some reason, but nobody knows for sure. Everybody hates it and tries to remove it, to no avail: the file will respawn the next time you open MS Office. The file is completely useless, as far as anybody can tell.
I don't suggest a solution to the issue, nor an explanation; just a cool workaround to have that file delete itself every time you open its containing folder. It does so by means of a Folder Action. Folder Actions are pieces of AppleScript code to be executed automatically every time you open or close a folder, or add/remove items to/from it.
Here's how to create the one we need. Open Script Editor (in Applications » AppleScript) and type the following script and then click Compile to test for (most) spelling mistakes:
on opening folder
tell application "Finder" to delete file "profiles.bin" of home
end opening folder
Save the script as Delete profiles_bin somewhere appropriate, such as in Home » Library » Scripts » Folder Action Scripts (this is where Automator saves its folder actions), then open a Finder window. Control-clik on your home folder in the sidebar and select Enable Folder Actions. From the same menu, choose "Attach a Folder Action" and point it to the file you just saved
Mac OS X Hints
http://hints.macworld.com/article.php?story=20070803144536276