With USB Overdrive, I can set up the buttons for any specific application. With the mouse being Bluetooth, it also works across my entire house. This hint isn't specifically for this mouse though, as any wireless mouse would work the same, although maybe not as far.
Here's one way I use it, with Front Row. Front Row can be controlled from the keyboard using the arrow keys and others. As such, it's trivial to program USB Overdrive to operate Front Row by matching the mouse buttons to the Front Row keyboard keys. I have my Mac connected to a TV as a second monitor, so I just active Front Row on my mac, then carry the mouse into the living room, and it operates flawlessly. The right and left mouse buttons cycle through the selections, the scroll wheel moves up and down the menus, the middle muse button makes my selection, etc...
I wanted to share this because everyone has a mouse, so everyone has a "remote," too. Sometimes there's no need to buy extra equipment to do something. You can download and try USB Overdrive for free, and if you like it, the cost is small.

