Linotype has recently released an excellent font manager called FontExplorer X that I highly recommend for service bureaus and designers. Its iTunes-like interface and speed make it perfect for activating thousands of fonts with excellent performance -- it was discussed in this recent hint.
This application doesn't normally work with network homes in a Mac OS X Server environment, but a simple symbolic link can fix the problem:
ln -s /Users/Shared/Linotype-user_name ~/Library/Caches/Linotype
Mac OS X Hints
http://hints.macworld.com/article.php?story=20051001130716148