First, create a file (I named mine virtualhosts.conf), and place it in /etc -> httpd -> users. Place the following inside:
# you can put anything after /.vh/ as longs as
# it starts with the site name followed by an
# optional path
RegisterResource "MacOS X Hints" /.vh/www.macosxhints.com/
RegisterResource "Send me one, please!" /.vh/www.apple.com/displays/
# Add other RegisterResource as above to add more sites
# Magic.....
RewriteEngine On
RewriteRule /\.vh/(.+) http://$1 [R]
Next, restart your Apache webserver:
$ sudo apachectl stop
$ sudo apachectl start
You can also restart with sudo apachectl restart or even sudo apachectl graceful. I prefer stop/start, though. That's it. Check your Rendezvous menu in the Bookmarks Bar in Safari, and you'll find a "MacOS X Hints" entry that will redirect to this site. We can also use this method to support HTTPS. Just add this line to the file:
RewriteRule /\.vhs/(.+) https://$1 [R]
And register resources as:
RegisterResource "Amazon" /.vhs/www.amazon.com/
We use a prefix, /.vh/ (and /.vhs/), that should be unused in most configurations. If you happen to use it in your own configuration, change all the occurrences to something else, like /.idontusethis/.

