Also somewhat oddly, TextEdit deselects after you make a change with the Find/Replace box. That is, your selection does not remain selected. You can't do, for example, two different Find/Replaces consecutively on the same selected text. You'll have to go back to the TextEdit page and re-select your text.

The good news is, the Find/Replace box is non-modal, meaning you can leave it on the screen while you re-select text--you don't have to close it. Something common in OSX, I know, but worth pointing out because many of us have developed habits based on older OSes. I catch myself closing boxes like the Find/Replace box just because I am used to the idea that I must.

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osxpounder