There are several hints that discuss disabling or changing the font smoothing threshold with the defaults key AppleAntiAliasingThreshold. However, this does not affect certain monospace fonts such as 10 pt Monaco, which is used in TextEdit, Mail, Xcode, etc. To make these fonts smoothed, try:
defaults write .GlobalPreferences AppleSmoothFixedFontsSizeThreshold 4
Substitute whatever number you want for the smoothing threshold (4 in the above example). As with any defaults command, you can also set the value on a per-application basis by substituting the com.company.product preference name for .GlobalPreferences.
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