If you have Photoshop installed, then you might have noticed about 15 different items in the Open With... menu when you use this on an image. To get rid of these extra items go to /Applications/Adobe Photoshop 7.0/Presets and delete the directory "Presets".
NOTE: This will permanently remove these droplets and they will be gone until you reinstall Photoshop
This slims the Open With... menu down a ton, and gives you a huge speed boost when trying to use it.
Mac OS X Hints
http://hints.macworld.com/article.php?story=20030207065422748