I can't say I've noticed any differences with iTunes, but here's my list of 10.2.1 observations:
- Great: Burned CD-Rs with contents in folders can again be read by Windows machines!
- Good: Finder FTP connections now work much more reliably
- Good: Fixed a problem with my UMAX 600S SCSI scanner
- Good: Mail feels much snappier
- Good: Not sure what they changed, but it sure seems like web pages are loading much faster now!
- Bad: Mail still has the copy/paste bug where an extra character is added at the front of copied text. At least now the bad character is visible, but I'll still be getting 10 emails a week complaining that the username and password assigned by macosxhints.com fail when the user tries to login. So please, don't copy/paste the username and password from Mail when you first try to login ;-)
- Bad: You can still mess up your desktop icons by dragging one off the left edge of the screen; the ones on the right will jump off the right edge!

